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  • Nature Chemical Biology

    Nature Chemical Biology is an interdisciplinary journal that publishes the most innovative and important research advances at the interface of chemistry and biology. The journal publishes research from chemists who are applying the principles, language and tools of chemistry to biological systems and from biologists who are interested in understanding biological processes at the molecular level. The scope of the journal covers all areas of contemporary research at the interface of chemistry and biology.

    Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning

    https://www.nature.com/articles/s41589-025-02083-z
    Karla M. Castro

    Configurational isomerization around the metal center underlies chemoselectivity of a radical halogenase

    https://www.nature.com/articles/s41589-025-02078-w

    When membrane proteins prefer lipids

    https://www.nature.com/articles/s41589-025-02084-y
    Edward Lyman

    Mapping cellular contacts in situ

    https://www.nature.com/articles/s41589-025-02080-2
    Anfei Huang

    Gluing the allosteric way

    https://www.nature.com/articles/s41589-025-02059-z
    Laura A. Schneider

    Acid enables biogenic crystallization

    https://www.nature.com/articles/s41589-025-02079-9
    Florent Figon

    Redirecting endogenous allies

    https://www.nature.com/articles/s41589-025-02072-2
    Ieva Savickyte

    SINE compounds activate exportin 1 degradation through an allosteric mechanism

    https://www.nature.com/articles/s41589-025-02058-0
    Casey E. Wing