Nature Chemical Biology

Nature Chemical Biology is an interdisciplinary journal that publishes the most innovative and important research advances at the interface of chemistry and biology. The journal publishes research from chemists who are applying the principles, language and tools of chemistry to biological systems and from biologists who are interested in understanding biological processes at the molecular level. The scope of the journal covers all areas of contemporary research at the interface of chemistry and biology.

Mechanism of the M. tuberculosis DprE1–DprE2 epimerase complex and inhibition by anti-tubercular drugs

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α2,6-Sialoglycan-regulated antitumor immunity of tumor-infiltrating CD8⁺ T cells

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Adaptive mechanisms and emerging cancer therapeutics for CDK2 inhibitors

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A safety pin against BAX

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An enantioselective covalent inhibitor of BAX confers cytoprotection in vivo

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CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics

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Topogenic sequence recognition at TIM complexes revealed by a stendomycin-bound structure

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Entering the agentic era of AI in drug discovery

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