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  • Nature Methods

    Nature Methods offers a unique interdisciplinary forum for the publication of novel methods. Nature Methods focuses on the life sciences, combining practical, technique-driven subject matter with rigorous peer-review standards to ensure that readers are consistently presented with only the most valuable and highest quality methodological research. The journal offers its readers primary research papers as well as an array of opinions, reviews and short journalistic pieces to provide busy researchers with a broad, yet easily absorbed perspective of important methodological developments in the life sciences.

    Multi-immersion oblique plane microscope (miOPM): a reconfigurable platform for high-resolution light-sheet fluorescence microscopy

    https://www.nature.com/articles/s41592-026-03245-0
    Bingying Chen

    Recent developments of fluorescent proteins and biosensors driven by cross-disciplinary insights

    https://www.nature.com/articles/s41592-026-03268-7
    Anneliese M. M. Gest

    AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes

    https://www.nature.com/articles/s41592-026-03264-x
    Jens Luebeck

    Integrating sex as a biological variable into one’s science

    https://www.nature.com/articles/s41592-026-03266-9
    Vivien Marx

    LoL-align: sensitive and fast probabilistic protein structure alignment

    https://www.nature.com/articles/s41592-026-03249-w
    Lasse Reifenrath

    MassNet: billion-scale AI-ready mass spectral corpus empowering scalable deep learning in proteomics

    https://www.nature.com/articles/s41592-026-03247-y
    Jun A

    The companion website

    https://www.nature.com/articles/s41592-026-03276-7
    Andreas Bueckle

    Near-infrared photochromic miniprotein enables photoacoustic molecular imaging of acute inflammation and intracellular antigens

    https://www.nature.com/articles/s41592-026-03255-y
    Olena S. Oliinyk